Quaternary structure: Binds the alpha(V)beta(3)-integrin. The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic
labelling for nucleobindin and osteoadherin from Lowicryl sections of bone, and valproate act differently on rat bone mass, structure, and metabolism.
Utility Header Menu Right. 800-343-7475; Contact Us; Cart Structure. Like other glycosaminoglycans keratan sulfate is a linear polymer that consists of a repeating disaccharide unit. Keratan sulfate occurs as a proteoglycan (PG) in which KS chains are attached to cell-surface or extracellular matrix proteins, termed core proteins.
KS chains in fibromodulin and osteoadherin are relatively short (8–9 disaccharides) and are more highly sulfated than KS in cornea (Lauder et al., 1997). Different subclasses of proteoglycan are generally characterized by the structure of the core protein and by the nature of the GAG. biglycan, fibromodulin, and osteoadherin, Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Background Small leucine-rich repeat protein (SLRP) family members contain conserved leucine-rich repeat motifs flanked by highly variable N- and C-terminal regions. Most class II and III SLRPs have tyrosine-rich N-terminal regions and some of these are sulfated.
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Strip well format. Reagents for up to 96 tests. This human Osteoadherin ELISA Kit is based on standard sandwich enzyme-link Osteoadherin is a close relative to fibromodulin within the leucine-rich repeat protein family.
(1998) Sommarin et al. Journal of Biological Chemistry. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α(v)/β3])-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegard, D. (1998) J. Cell Biol. 141, 839- 847). The primary structure
800-343-7475; Contact Us; Cart GeneCards Summary for OMD Gene. OMD (Osteomodulin) is a Protein Coding gene.
141, 839- 847). The primary structure
Thus the intensity of the immunogold signal for two bone proteins (Nucleobindin (Nuc) and osteoadherin (OSAD)) was compared in retrieved and non-retrieved sections of PFF rat bone. As an additional experiment, the effect of antigen retrieval (for Nuc) in sections of tissue primary stabilized by high pressure freezing with subsequent freeze substitution (HPF-FS) was studied. Cell therapy is a promising treatment modality to improve heart function in acute myocardial infarction.
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Osteoadherin is a close relative to fibromodulin within the leucine-rich repeat protein family. The two proteins differ in the distribution of the sulfate residues in their tyrosine-rich N-terminal domains. However, they showed similarities in binding of the heparin-binding proteins. Country/Region selector.
The entire translated primary sequence corresponds to a 49,116-Da protein with a calculated isoelectric point for the mature protein of 5.2. 1999-12-30
Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucinerich proteoglycans (SLRP). LRR motifs consist of approximately 2030 amino acids (aa) with conserved leucine spacing, folded into a structure with one βsheet and one
Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is encoded by the OMD gene. References Further reading.
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labelling for nucleobindin and osteoadherin from Lowicryl sections of bone, and valproate act differently on rat bone mass, structure, and metabolism.
The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone from a primary 1998-07-03 · In order to further characterize osteoadherin, we have determined its primary structure. This reveals that osteoadherin belongs to the LRR family of connective tissue proteins. Osteoadherin is primarily expressed by mature osteoblasts, as shown in studies of its expression by in situ hybridization. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate.
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27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is
Bone matrix.